Product Description: thioredoxin 3
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Process | GO:0045454 | cell redox homeostasis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.13 | 0.91 |
| Schizont | not expressed | 0.08 | 0.94 |
| Gametocyte | not expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0916100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.864 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0817100)
Modification: Other | RMgm-449
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q4VWQ3
"Best" AlphaFill ligand hit: COM (1-thioethanesulfonic acid, Local RMSD=0.27) with 4POK (Global RMSD=2.03)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 4 | 14 |
| disruptive | 6 | 19 | 12 | 35 |
| missense | 6 | 19 | 12 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 25 | 10 | 10 |
| disruptive | 8 | 57 | 25 | 48 |
| missense | 8 | 48 | 20 | 34 |
PlasmoDB Total SNPs: 89
Non-coding: 79 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 2
Protein Length: 180 | Molecular Weight (kDa): 20.941
UniProt ID(s): Q4VWQ3
PDB ID(s): 3CXG
Isoelectric Point: 8.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00085 | Thioredoxin domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 21203490 | Compartmentation of redox metabolism in malaria parasites. | Kehr S, Sturm N, ..., Becker K | 10.1371/journal.ppat.1001242 |
| 20707985 | Assessment of chronological lifespan dependent molecular damages in yeast lackingmitochondrial antioxidant genes | Demir AB, Koc A | 10.1016/j.bbrc.2010.08.019 |
| 33101372 | Functional Characterization of a Novel Oxidative Stress Protection Protein in thePathogenic Yeast Candida glabrata | Usher J, Chaudhari Y, ..., Haynes K | 10.3389/fgene.2020.530915 |
| 33546197 | Screening and Genetic Network Analysis of Genes Involved in Freezing and ThawingResistance in DaMDHAR-Expressing Saccharomyces cerevisiae Using Gene ExpressionProfiling | Kim IS, Choi W, ..., Kim HW | 10.3390/genes12020219 |
| 28418643 | Diphenyl Diselenide Protects against Methylmercury-Induced Toxicity inSaccharomyces cerevisiae via the Yap1 Transcription Factor | Lovato FL, Teixeira da Rocha JB, Dalla Corte CL | 10.1021/acs.chemrestox.6b00449 |
| 22770501 | Oxidation of the yeast mitochondrial thioredoxin promotes cell death | Greetham D, Kritsiligkou P, ..., Grant CM | 10.1089/ars.2012.4597 |
| 22806013 | Glutathione reductase from Brassica rapa affects tolerance and the redox statebut not fermentation ability in response to oxidative stress in geneticallymodified Saccharomyces cerevisiae | Yoon HS, Shin SY, Kim YS, Kim IS | 10.1007/s11274-011-0988-8 |
| 22609415 | Effects of Trx2p and Sec23p expression on stable production of hepatitis Bsurface antigen S domain in recombinant Saccharomyces cerevisiae | Park YK, Jung SM, ..., Seo JH | 10.1016/j.jbiotec.2012.05.001 |
| 21763276 | Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed inmitochondria and involved in sporulation | Ukai Y, Kishimoto T, ..., Inoue Y | 10.1016/j.bbrc.2011.06.189 |
| 22279963 | Pap1p-dependent upregulation of thioredoxin 3 and thioredoxin reductase genesfrom the fission yeast under nitrosative stress | Park MS, Kim HJ, ..., Lim CJ | 10.1139/w11-125 |