About Gene List

PF3D7_0916200

Genome location: Pf3D7_09_v3:675,629..679,979(+)

Genome classification: Core

Function and Localization

Product Description: mitochondrial ribonuclease P catalytic subunit, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Function GO:0004526 ribonuclease P activity
Process GO:0001682 tRNA 5'-leader removal

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.17 0.92
Trophozoite expressed 0.88 0.54
Schizont expressed 0.19 0.88
Gametocyte expressed 0.90 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0916200

Resistome Missense Mutations: S1050F

Resistome Compounds with Missense Mutations: AUY922

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.944 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Z0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533330

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 57 37 93
disruptive 23 95 74 156
missense 22 93 69 137

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 125 58 88
disruptive 31 263 90 259
missense 26 234 74 179

PlasmoDB Total SNPs: 170

Non-coding: 104 | Synonymous: 38 | Nonsynonymous: 27 | Stop Codon: 1

Protein Information

Protein Length: 1144 | Molecular Weight (kDa): 136.77

UniProt ID(s): Q8I2Z0

PDB ID(s): None

Isoelectric Point: 9.11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR033495 Mitochondrial ribonuclease P catalytic subunit
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895