PF3D7_0916300

Genome location: Pf3D7_09_v3:680,231..681,984(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.11	0.92
Gametocyte	expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0916300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.138 | MFS: -3.23 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0817300)

Relative Growth Rate: 0.10 ± 0.12
Confidence: 5.59

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Y9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533721

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	19	7	32
disruptive	4	14	10	29
missense	4	12	10	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	36	17	26
disruptive	10	33	22	57
missense	8	26	19	41

PlasmoDB Total SNPs: 247

Non-coding: 224 | Synonymous: 21 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 292 | Molecular Weight (kDa): 34.412

UniProt ID(s): Q8I2Y9

PDB ID(s): None

Isoelectric Point: 7.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095