PF3D7_0916400

Genome location: Pf3D7_09_v3:683,244..691,188(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.01	0.56
Trophozoite	expressed	1.02	0.49
Schizont	expressed	0.64	0.65
Gametocyte	possibly expressed	1.35	0.37

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0916400

Resistome Missense Mutations: K388Q

Resistome Compounds with Missense Mutations: BRD1095

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.867 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H539

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533398

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	37	125	86	168
disruptive	159	516	277	623
missense	115	450	247	493

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	60	267	124	220
disruptive	346	1177	429	1001
missense	214	929	331	589

PlasmoDB Total SNPs: 471

Non-coding: 55 | Synonymous: 226 | Nonsynonymous: 187 | Stop Codon: 3

Protein Information

Protein Length: 2519 | Molecular Weight (kDa): 305.333

UniProt ID(s): C0H539

PDB ID(s): None

Isoelectric Point: 9.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A