PF3D7_0916500 (UFD1)

Genome location: Pf3D7_09_v3:691,282..694,189(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin fusion degradation protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex
Component	GO:0020011	apicoplast
Function	GO:0016887	ATP hydrolysis activity
Function	GO:0031593	polyubiquitin modification-dependent protein binding
Process	GO:0071712	ER-associated misfolded protein catabolic process
Process	GO:0010564	regulation of cell cycle process
Process	GO:0030433	ubiquitin-dependent ERAD pathway

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.22	0.86
Schizont	expressed	0.05	0.97
Gametocyte	expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0916500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.673 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H540

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134702

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	23	19	23
disruptive	3	28	12	59
missense	3	27	12	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	50	18	25
disruptive	8	76	34	97
missense	7	64	31	70

PlasmoDB Total SNPs: 239

Non-coding: 222 | Synonymous: 13 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 296 | Molecular Weight (kDa): 34.942

UniProt ID(s): A0MNT9, C0H540

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004854	Ubiquitin fusion degradation protein Ufd1-like
PFam	PF03152	Ubiquitin fusion degradation protein Ufd1-like
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
19502583	An unusual ERAD-like complex is targeted to the apicoplast of Plasmodiumfalciparum.	Spork S, Hiss JA, ..., Przyborski JM	10.1128/EC.00083-09
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895