About Gene List

PF3D7_0917000 (MOP)

Genome location: Pf3D7_09_v3:706,053..712,389(-)

Genome classification: Core

Function and Localization

Product Description: merozoite organizing protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0000793 condensed chromosome
Component GO:0000796 condensin complex
Process GO:0051301 cell division
Process GO:0007076 mitotic chromosome condensation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite expressed 0.65 0.64
Schizont expressed 0.77 0.57
Gametocyte expressed 0.43 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0917000

Resistome Missense Mutations: D847G

Resistome Compounds with Missense Mutations: MMV006901

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.016 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0818000)

  • Relative Growth Rate: 0.26 ± 0.28
  • Confidence: 3.93

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Y3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_194539

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 98 93 149
disruptive 42 198 109 301
missense 21 173 93 260

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 31 218 118 148
disruptive 77 418 211 426
missense 39 348 178 305

PlasmoDB Total SNPs: 199

Non-coding: 37 | Synonymous: 118 | Nonsynonymous: 44 | Stop Codon: 0

Protein Information

Protein Length: 1826 | Molecular Weight (kDa): 215.35

UniProt ID(s): Q8I2Y3

PDB ID(s): None

Isoelectric Point: 5.82

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016024 Armadillo-type fold
InterPro IPR027165 Condensin complex subunit 3
PFam N/A N/A
Superfamily SSF48371 Armadillo-type fold

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
27121004 An essential malaria protein defines the architecture of blood-stage andtransmission-stage parasites. Absalon S, Robbins JA, Dvorin JD 10.1038/ncomms11449
32049018 Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. Pandey R, Abel S, ..., Tewari R 10.1016/j.celrep.2020.01.033