PF3D7_0917200

Genome location: Pf3D7_09_v3:716,325..717,506(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	possibly expressed	0.01	1.00
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0917200

Resistome Missense Mutations: I49L

Resistome Compounds with Missense Mutations: MMV006901, MMV407834, OSM-S-106

Resistome # Samples with Disruptive Mutations: 14 (14 missense, 14 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.119 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Y1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533373

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	21	18	19
disruptive	3	26	13	31
missense	3	26	12	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	45	11	21
disruptive	12	51	37	78
missense	7	41	26	54

PlasmoDB Total SNPs: 34

Non-coding: 13 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 1

Protein Information

Protein Length: 324 | Molecular Weight (kDa): 38.754

UniProt ID(s): Q8I2Y1

PDB ID(s): None

Isoelectric Point: 8.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A