PF3D7_0917400

Genome location: Pf3D7_09_v3:720,420..726,262(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	possibly expressed	0.56	0.69
Gametocyte	not expressed	0.37	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0917400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.653 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2X9

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=2.31) with 6OQ7 (Global RMSD=34.96)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532900

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	77	46	115
disruptive	39	286	179	323
missense	35	264	169	296

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	154	64	114
disruptive	103	584	246	379
missense	72	520	225	298

PlasmoDB Total SNPs: 258

Non-coding: 133 | Synonymous: 69 | Nonsynonymous: 56 | Stop Codon: 0

Protein Information

Protein Length: 1291 | Molecular Weight (kDa): 153.981

UniProt ID(s): Q8I2X9

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A