PF3D7_0917500

Genome location: Pf3D7_09_v3:726,278..729,348(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.53	0.69
Schizont	expressed	0.20	0.86
Gametocyte	expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0917500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.143 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0818500)

Relative Growth Rate: 0.12 ± 0.07
Confidence: 6.59

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2X8

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.07) with 6JWR (Global RMSD=15.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171463

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	38	26	37
disruptive	19	60	32	84
missense	15	56	27	75

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	70	30	49
disruptive	28	121	70	163
missense	21	95	57	104

PlasmoDB Total SNPs: 139

Non-coding: 90 | Synonymous: 30 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 681 | Molecular Weight (kDa): 79.675

UniProt ID(s): Q8I2X8

PDB ID(s): None

Isoelectric Point: 6.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	N/A	N/A
Superfamily	SSF46565	Chaperone J-domain superfamily