PF3D7_0917800

Genome location: Pf3D7_09_v3:734,361..736,105(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	not expressed	0.13	0.91
Schizont	not expressed	0.09	0.93
Gametocyte	not expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0917800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.45 | MFS: -2.764 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2X5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532469

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	22	13	24
disruptive	9	40	23	51
missense	9	39	23	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	42	20	23
disruptive	16	89	49	101
missense	16	71	47	72

PlasmoDB Total SNPs: 65

Non-coding: 40 | Synonymous: 13 | Nonsynonymous: 11 | Stop Codon: 1

Protein Information

Protein Length: 437 | Molecular Weight (kDa): 52.382

UniProt ID(s): Q8I2X5

PDB ID(s): None

Isoelectric Point: 8.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A