PF3D7_0918100

Genome location: Pf3D7_09_v3:746,396..749,301(+)

Genome classification: Core

Function and Localization

Product Description: cytochrome b5-like heme/steroid binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0918100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.156 | MFS: -2.805 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0819100)

• Relative Growth Rate: 0.74 ± 0.13
• Confidence: 5.52

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0819100)

Modification: Disrupted | RMgm-2379

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H542

"Best" AlphaFill ligand hit: OCT (n-octane, Local RMSD=0.28) with 4PR7 (Global RMSD=18.90)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102017

Most Similar Human Ortholog: A0A0A0MRM6

TM-align score: 0.78 | RMSD: 1.68

Seq Identity: 0.36 | Length: 95 / 130

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 238

Non-coding: 219 | Synonymous: 3 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 130 | Molecular Weight (kDa): 15.223

UniProt ID(s): C0H542

PDB ID(s): None

Isoelectric Point: 9.89

Protein Domain Annotations: