PF3D7_0918200

Genome location: Pf3D7_09_v3:748,534..750,334(-)

Genome classification: Core

Function and Localization

Product Description: 50S ribosomal protein L3, apicoplast, putative

SignalP Peptide: MPLFFLYSFLIYLILFQCIRN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Function	GO:0003735	structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0918200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.784 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1458600)

Relative Growth Rate: 0.18 ± 0.08
Confidence: 6.39

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H543

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100949

Most Similar Human Ortholog: D6RC14

TM-align score: 0.85 | RMSD: 1.80

Seq Identity: 0.27 | Length: 146 / 317

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000114686	mitochondrial ribosomal protein L3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	32	9	30
disruptive	3	15	8	29
missense	3	14	8	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	51	16	23
disruptive	5	31	24	71
missense	5	25	23	52

PlasmoDB Total SNPs: 95

Non-coding: 89 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 317 | Molecular Weight (kDa): 36.275

UniProt ID(s): C0H543

PDB ID(s): None

Isoelectric Point: 10.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000597	Ribosomal protein L3
InterPro	IPR009000	Translation protein, beta-barrel domain superfamily
InterPro	IPR019926	Ribosomal protein L3, conserved site
InterPro	IPR019927	Ribosomal protein L3, bacterial/organelle-type
PFam	PF00297	Ribosomal protein L3
Superfamily	SSF50447	Translation protein, beta-barrel domain superfamily