Product Description: eukaryotic translation initiation factor 3 subunit F, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m |
| Component | GO:0005634 | nucleus |
| Function | GO:0003743 | translation initiation factor activity |
| Function | GO:0031369 | translation initiation factor binding |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.26 | 0.84 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0918300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.983 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2X0
"Best" AlphaFill ligand hit: ETE (2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol, Local RMSD=1.55) with 2O95 (Global RMSD=3.57)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103242
Most Similar Human Ortholog: E9PQV8
TM-align score: 0.74 | RMSD: 1.21
Seq Identity: 0.09 | Length: 43 / 320
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000175390 | eukaryotic translation initiation factor 3 subunit F |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 14 | 26 |
| disruptive | 2 | 11 | 8 | 31 |
| missense | 2 | 10 | 8 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 37 | 19 | 27 |
| disruptive | 4 | 41 | 23 | 77 |
| missense | 2 | 35 | 19 | 52 |
PlasmoDB Total SNPs: 146
Non-coding: 125 | Synonymous: 14 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 320 | Molecular Weight (kDa): 36.82
UniProt ID(s): Q8I2X0
PDB ID(s): None
Isoelectric Point: 6.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000555 | JAB1/MPN/MOV34 metalloenzyme domain |
| InterPro | IPR024969 | Rpn11/EIF3F, C-terminal |
| InterPro | IPR027531 | Eukaryotic translation initiation factor 3 subunit F |
| PFam | PF01398 | JAB1/MPN/MOV34 metalloenzyme domain |
| PFam | PF13012 | Rpn11/EIF3F, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37352983 | Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGGrepeat-associated toxicity in a Drosophila model of FXTAS | Malik I, Tseng YJ, ..., Todd PK | 10.1016/j.nbd.2023.106212 |