About Gene List

PF3D7_0918400

Genome location: Pf3D7_09_v3:754,297..760,269(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MCIYFFLFLFIITSCNN

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite possibly expressed 0.03 0.98
Schizont possibly expressed 0.02 0.99
Gametocyte possibly expressed 0.58 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0918400

Resistome Missense Mutations: H1538N

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.536 | #Insertions: 6

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0819400)

  • Relative Growth Rate: 1.04 ± 0.15
  • Confidence: 5.14

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0819400)

Modification: Disrupted | RMgm-2381

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H544

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145679

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 80 48 103
disruptive 32 95 60 161
missense 26 83 53 135

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 151 75 102
disruptive 53 210 112 279
missense 36 156 93 205

PlasmoDB Total SNPs: 213

Non-coding: 92 | Synonymous: 92 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 1720 | Molecular Weight (kDa): 205.672

UniProt ID(s): C0H544

PDB ID(s): None

Isoelectric Point: 8.68

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000742 EGF-like domain
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895