About Gene List

PF3D7_0918700

Genome location: Pf3D7_09_v3:769,319..772,498(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.07 0.54
Trophozoite not expressed 0.09 0.95
Schizont expressed 0.23 0.87
Gametocyte expressed 0.19 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0918700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.728 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2W6

"Best" AlphaFill ligand hit: B3P (2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol, Local RMSD=2.45) with 5NFV (Global RMSD=37.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532566

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 34 22 51
disruptive 54 154 74 166
missense 32 137 63 146

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 84 35 38
disruptive 95 318 123 258
missense 60 269 92 161

PlasmoDB Total SNPs: 259

Non-coding: 96 | Synonymous: 81 | Nonsynonymous: 82 | Stop Codon: 0

Protein Information

Protein Length: 737 | Molecular Weight (kDa): 84.256

UniProt ID(s): Q8I2W6

PDB ID(s): None

Isoelectric Point: 4.99

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108