Product Description: nucleosome assembly protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0000123 | histone acetyltransferase complex |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.25 | 0.46 |
| Trophozoite | expressed | 1.06 | 0.46 |
| Schizont | expressed | 0.39 | 0.76 |
| Gametocyte | expressed | 0.70 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0919000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.888 | MFS: -2.21 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0819900)
Modification: Tagged | RMgm-218
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2W3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103113
Most Similar Human Ortholog: A0A0C4DFV9
TM-align score: 0.69 | RMSD: 3.02
Seq Identity: 0.28 | Length: 209 / 269
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119335 | SET nuclear proto-oncogene |
| ENSG00000230667 | SET like protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 5 | 13 |
| disruptive | 3 | 12 | 6 | 20 |
| missense | 1 | 4 | 3 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 30 | 10 | 11 |
| disruptive | 5 | 28 | 19 | 51 |
| missense | 1 | 11 | 12 | 30 |
PlasmoDB Total SNPs: 136
Non-coding: 120 | Synonymous: 14 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 269 | Molecular Weight (kDa): 31.827
UniProt ID(s): O76970, Q8I2W3, Q8I9F4, Q9Y010
PDB ID(s): None
Isoelectric Point: 3.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002164 | Nucleosome assembly protein (NAP) |
| InterPro | IPR037231 | NAP-like superfamily |
| PFam | PF00956 | Nucleosome assembly protein (NAP) |
| Superfamily | SSF143113 | NAP-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15899528 | Biochemical characterization of the two nucleosome assembly proteins fromPlasmodium falciparum. | Chandra BR, Olivieri A, ..., Sharma A | 10.1016/j.molbiopara.2005.04.006 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16638744 | The two Plasmodium falciparum nucleosome assembly proteins play distinct roles inhistone transport and chromatin assembly. | Navadgi VM, Chandra BR, Mishra PC, Sharma A | 10.1074/jbc.M602243200 |
| 19765590 | Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum. | Volz J, Carvalho TG, ..., Cowman AF | 10.1016/j.ijpara.2009.09.002 |
| 20377878 | Structure, localization and histone binding properties of nuclear-associatednucleosome assembly protein from Plasmodium falciparum. | Gill J, Kumar A, ..., Sharma A | 10.1186/1475-2875-9-90 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34403450 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. | Miao J, Wang C, ..., Cui L | 10.1371/journal.ppat.1009351 |
| 38286376 | In vitro digestion and fecal fermentation of basidiospore-derivedexopolysaccharides from Naematelia aurantialba | Sun T, Liang X, ..., Lei P | 10.1016/j.ijbiomac.2024.129756 |