PF3D7_0919100

Genome location: Pf3D7_09_v3:785,169..789,003(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.66	0.69
Trophozoite	expressed	1.08	0.45
Schizont	expressed	0.55	0.69
Gametocyte	expressed	0.77	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0919100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.16 | MFS: -2.748 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0820000)

Relative Growth Rate: 0.16 ± 0.10
Confidence: 6.01

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2W2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130921

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	28	9	29
disruptive	2	5	7	18
missense	2	5	6	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	47	8	28
disruptive	2	37	31	76
missense	2	22	22	48

PlasmoDB Total SNPs: 162

Non-coding: 135 | Synonymous: 24 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 370 | Molecular Weight (kDa): 43.26

UniProt ID(s): Q8I2W2

PDB ID(s): None

Isoelectric Point: 8.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR018253	DnaJ domain, conserved site
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
Superfamily	SSF46565	Chaperone J-domain superfamily