About Gene List

PF3D7_0919300 (TrxL1)

Genome location: Pf3D7_09_v3:792,890..794,428(+)

Genome classification: Core

Function and Localization

Product Description: thioredoxin-like protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005875 microtubule associated complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.09 0.95
Trophozoite possibly expressed 0.01 1.00
Schizont expressed 0.11 0.94
Gametocyte expressed 0.05 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0919300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.153 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0820200)

  • Relative Growth Rate: 1.05 ± 0.17
  • Confidence: 4.90

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0820200)

Modification: Tagged | RMgm-5317

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2W0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_118095

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 15 9 25
disruptive 2 8 7 21
missense 2 7 7 20

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 33 10 22
disruptive 2 26 19 59
missense 2 19 19 44

PlasmoDB Total SNPs: 65

Non-coding: 52 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 207 | Molecular Weight (kDa): 23.657

UniProt ID(s): Q8I2W0

PDB ID(s): None

Isoelectric Point: 7.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR012336 Thioredoxin-like fold
InterPro IPR036249 Thioredoxin-like superfamily
PFam PF13905 Thioredoxin-like fold
Superfamily SSF52833 Thioredoxin-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23873863 Novel thioredoxin-like proteins are components of a protein complex coating thecortical microtubules of Toxoplasma gondii. Liu J, Wetzel L, ..., Hu K 10.1128/EC.00082-13
34031406 Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondiiidentifies their microtubule inner proteins Wang X, Fu Y, ..., Zhang R 10.1038/s41467-021-23351-1