PF3D7_0919800

Genome location: Pf3D7_09_v3:803,743..808,112(-)

Genome classification: Core

Function and Localization

Product Description: TLD domain-containing protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.54	0.75
Trophozoite	expressed	0.81	0.58
Schizont	expressed	1.12	0.45
Gametocyte	expressed	0.93	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0919800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.232 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2V5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100646

Most Similar Human Ortholog: E9PLW2

TM-align score: 0.92 | RMSD: 1.21

Seq Identity: 0.34 | Length: 115 / 1078

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101342	TBC/LysM-associated domain containing 2
ENSG00000111912	nuclear receptor coactivator 7
ENSG00000164830	oxidation resistance 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	60	32	86
disruptive	78	190	95	227
missense	45	133	80	175

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	123	46	94
disruptive	135	381	145	302
missense	68	280	117	217

PlasmoDB Total SNPs: 279

Non-coding: 112 | Synonymous: 67 | Nonsynonymous: 98 | Stop Codon: 2

Protein Information

Protein Length: 1078 | Molecular Weight (kDa): 124.916

UniProt ID(s): Q8I2V5

PDB ID(s): None

Isoelectric Point: 6.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006571	TLDc domain
PFam	PF07534	TLDc domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108