Genome location: Pf3D7_09_v3:809,430..821,487(-)
Genome classification: Core
Product Description: regulator of chromosome condensation-PP1-interacting protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.18 | 0.92 |
| Trophozoite | expressed | 1.06 | 0.54 |
| Schizont | expressed | 2.21 | 0.31 |
| Gametocyte | expressed | 1.93 | 0.20 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0919900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.216 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 44 | 132 | 91 | 201 |
| disruptive | 229 | 661 | 308 | 725 |
| missense | 134 | 483 | 250 | 554 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 61 | 277 | 112 | 232 |
| disruptive | 380 | 1194 | 469 | 877 |
| missense | 216 | 895 | 349 | 626 |
PlasmoDB Total SNPs: 790
Non-coding: 168 | Synonymous: 303 | Nonsynonymous: 318 | Stop Codon: 1
Protein Length: 3381 | Molecular Weight (kDa): 396.152
UniProt ID(s): Q8I2V4
PDB ID(s): None
Isoelectric Point: 6.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000408 | Regulator of chromosome condensation, RCC1 |
| InterPro | IPR009091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| PFam | PF00415 | Regulator of chromosome condensation, RCC1 |
| Superfamily | SSF50985 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| Superfamily | SSF69349 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30429842 | Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Proteinin Plasmodium falciparum. | Lenne A, De Witte C, ..., Pierrot C | 10.3389/fmicb.2018.02617 |