Product Description: chaperone, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0044571 | [2Fe-2S] cluster assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.19 | 0.88 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | possibly expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0920100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.14 | MFS: -2.769 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0821000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0821000)
Modification: Disrupted | RMgm-2390
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H546
"Best" AlphaFill ligand hit: PMS (phenylmethanesulfonic acid, Local RMSD=0.43) with 2CBG (Global RMSD=19.39)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102596
Most Similar Human Ortholog: Q8IWL3
TM-align score: 0.75 | RMSD: 1.67
Seq Identity: 0.25 | Length: 189 / 249
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100209 | HscB mitochondrial iron-sulfur cluster cochaperone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 19 | 11 | 12 |
| disruptive | 5 | 25 | 17 | 39 |
| missense | 5 | 24 | 17 | 36 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 33 | 16 | 13 |
| disruptive | 7 | 77 | 35 | 57 |
| missense | 7 | 66 | 33 | 41 |
PlasmoDB Total SNPs: 143
Non-coding: 131 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 249 | Molecular Weight (kDa): 29.804
UniProt ID(s): C0H546
PDB ID(s): None
Isoelectric Point: 8.14
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR004640 | Co-chaperone Hsc20 |
| InterPro | IPR009073 | Co-chaperone HscB, C-terminal oligomerisation domain |
| InterPro | IPR036386 | HscB, C-terminal domain superfamily |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| PFam | PF07743 | Co-chaperone HscB, C-terminal oligomerisation domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| Superfamily | SSF47144 | HscB, C-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |