PF3D7_0920200

Genome location: Pf3D7_09_v3:827,405..830,952(-)

Genome classification: Core

Function and Localization

Product Description: CS domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	expressed	0.54	0.69
Schizont	expressed	0.29	0.83
Gametocyte	expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0920200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -2.869 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0821100)

Relative Growth Rate: 0.12 ± 0.05
Confidence: 7.50

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0821100)

Modification: Disrupted | RMgm-1294

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2V1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138294

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	56	39	63
disruptive	24	92	44	156
missense	13	83	41	131

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	106	51	78
disruptive	46	216	112	256
missense	25	169	92	187

PlasmoDB Total SNPs: 128

Non-coding: 35 | Synonymous: 43 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 983 | Molecular Weight (kDa): 116.523

UniProt ID(s): Q8I2V1

PDB ID(s): None

Isoelectric Point: 6.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007052	CS domain
InterPro	IPR008978	HSP20-like chaperone
InterPro	IPR037895	NudC domain-containing protein 1
PFam	PF04969	CS domain
Superfamily	SSF49764	HSP20-like chaperone

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895