PF3D7_0920300

Genome location: Pf3D7_09_v3:831,524..832,780(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNIFCFCLVISFLLFTKN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.17	0.89
Schizont	not expressed	0.08	0.95
Gametocyte	expressed	1.02	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0920300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.379 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0821200)

Modification: Tagged | RMgm-1142

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2V0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532649

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	7	7	16
disruptive	9	19	16	38
missense	9	18	14	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	19	6	10
disruptive	11	51	24	43
missense	10	46	23	37

PlasmoDB Total SNPs: 59

Non-coding: 41 | Synonymous: 8 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 187 | Molecular Weight (kDa): 22.144

UniProt ID(s): Q8I2V0

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A