PF3D7_0920400

Genome location: Pf3D7_09_v3:833,308..840,082(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.94
Trophozoite	possibly expressed	0.64	0.64
Schizont	possibly expressed	0.22	0.86
Gametocyte	not expressed	0.32	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0920400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.653 | #Insertions: 7

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0821300)

Relative Growth Rate: 0.79 ± 0.68
Confidence: 2.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0821300)

Modification: Disrupted | RMgm-2392

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2U9

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.51) with 6JWW (Global RMSD=23.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532886

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	95	47	115
disruptive	64	281	170	420
missense	41	236	160	349

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	46	166	79	135
disruptive	131	582	309	544
missense	81	477	250	377

PlasmoDB Total SNPs: 375

Non-coding: 151 | Synonymous: 133 | Nonsynonymous: 91 | Stop Codon: 0

Protein Information

Protein Length: 1852 | Molecular Weight (kDa): 224.488

UniProt ID(s): Q8I2U9

PDB ID(s): None

Isoelectric Point: 6.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A