PF3D7_0920500

Genome location: Pf3D7_09_v3:840,386..842,993(+)

Genome classification: Core

Function and Localization

Product Description: ADP-ribosylation factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0005737	cytoplasm
Function	GO:0005525	GTP binding
Process	GO:0006886	intracellular protein transport
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.41	0.77
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0920500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.82 | MFS: -2.01 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2U8

"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=0.05) with 2H57 (Global RMSD=2.47)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146119

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	2	10
disruptive	4	6	5	15
missense	4	6	5	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	21	3	9
disruptive	6	28	10	47
missense	6	17	9	29

PlasmoDB Total SNPs: 197

Non-coding: 187 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 191 | Molecular Weight (kDa): 22.115

UniProt ID(s): Q8I2U8

PDB ID(s): None

Isoelectric Point: 8.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006689	Small GTPase superfamily, ARF/SAR type
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00025	Small GTPase superfamily, ARF/SAR type
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase