About Gene List

PF3D7_0920600

Genome location: Pf3D7_09_v3:843,108..847,719(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MIKCIQLYVITVCILLINIAC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.09 0.95
Trophozoite not expressed 0.66 0.64
Schizont not expressed 0.63 0.65
Gametocyte not expressed 0.52 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0920600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -3.159 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2U7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532717

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 62 47 92
disruptive 35 167 82 252
missense 28 150 76 210

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 126 72 102
disruptive 91 336 172 412
missense 57 280 139 272

PlasmoDB Total SNPs: 154

Non-coding: 23 | Synonymous: 64 | Nonsynonymous: 67 | Stop Codon: 0

Protein Information

Protein Length: 1354 | Molecular Weight (kDa): 165.765

UniProt ID(s): Q8I2U7

PDB ID(s): None

Isoelectric Point: 8.39

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895