PF3D7_0921100

Genome location: Pf3D7_09_v3:860,933..863,136(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.21	0.88
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.919 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H547

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532894

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	13	8	8
disruptive	2	21	26	38
missense	2	21	24	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	24	8	13
disruptive	7	59	35	68
missense	7	51	23	43

PlasmoDB Total SNPs: 112

Non-coding: 95 | Synonymous: 8 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 225 | Molecular Weight (kDa): 27.289

UniProt ID(s): C0H547

PDB ID(s): None

Isoelectric Point: 10.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A