PF3D7_0921200

Genome location: Pf3D7_09_v3:862,525..870,954(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.70	0.68
Trophozoite	expressed	0.64	0.66
Schizont	expressed	0.12	0.93
Gametocyte	expressed	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.147 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H548

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121619

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	123	75	158
disruptive	113	352	196	537
missense	68	285	176	459

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	243	95	167
disruptive	187	712	347	668
missense	113	554	295	511

PlasmoDB Total SNPs: 370

Non-coding: 179 | Synonymous: 94 | Nonsynonymous: 97 | Stop Codon: 0

Protein Information

Protein Length: 2302 | Molecular Weight (kDa): 276.944

UniProt ID(s): C0H548

PDB ID(s): None

Isoelectric Point: 8.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A