About Gene List

PF3D7_0921300

Genome location: Pf3D7_09_v3:871,334..873,544(+)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite not expressed 0.18 0.88
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.11 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.918 | MFS: -2.73 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0822200)

  • Relative Growth Rate: 0.11 ± 0.14
  • Confidence: 5.30

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2U0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139495

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 28 19 45
disruptive 6 33 9 58
missense 6 31 8 51

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 61 24 44
disruptive 14 54 48 104
missense 13 45 34 76

PlasmoDB Total SNPs: 97

Non-coding: 76 | Synonymous: 15 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 486 | Molecular Weight (kDa): 58.738

UniProt ID(s): Q8I2U0

PDB ID(s): None

Isoelectric Point: 8.27

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21