PF3D7_0921600

Genome location: Pf3D7_09_v3:877,514..883,452(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.87	0.61
Trophozoite	possibly expressed	0.86	0.54
Schizont	expressed	0.23	0.86
Gametocyte	not expressed	0.73	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.879 | MFS: -2.206 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0822500)

Relative Growth Rate: 0.28 ± 0.13
Confidence: 5.52

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0822500)

Modification: Disrupted | RMgm-2398

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2T7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533205

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	90	51	101
disruptive	42	204	135	354
missense	40	198	121	315

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	167	64	129
disruptive	101	488	257	530
missense	73	420	220	386

PlasmoDB Total SNPs: 196

Non-coding: 99 | Synonymous: 46 | Nonsynonymous: 50 | Stop Codon: 1

Protein Information

Protein Length: 1650 | Molecular Weight (kDa): 198.031

UniProt ID(s): Q8I2T7

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily