About Gene List

PF3D7_0921700

Genome location: Pf3D7_09_v3:883,515..885,592(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.13 0.94
Trophozoite possibly expressed 0.88 0.54
Schizont expressed 0.36 0.79
Gametocyte not expressed 0.45 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -2.764 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2T6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146168

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 29 12 40
disruptive 29 67 28 77
missense 16 53 25 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 58 29 39
disruptive 47 138 62 166
missense 21 96 53 107

PlasmoDB Total SNPs: 76

Non-coding: 27 | Synonymous: 30 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 569 | Molecular Weight (kDa): 69.073

UniProt ID(s): Q8I2T6

PDB ID(s): None

Isoelectric Point: 10.02

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895