PF3D7_0921800 (RPF1)

Genome location: Pf3D7_09_v3:885,956..887,813(-)

Genome classification: Core

Function and Localization

Product Description: ribosome production factor 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Component	GO:0030687	preribosome, large subunit precursor
Process	GO:0000460	maturation of 5.8S rRNA
Process	GO:0000470	maturation of LSU-rRNA
Process	GO:0006364	rRNA processing
Process	GO:0000027	ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.19	0.90
Trophozoite	expressed	0.16	0.90
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.117 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H549

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102467

Most Similar Human Ortholog: Q9H9Y2

TM-align score: 0.87 | RMSD: 2.38

Seq Identity: 0.29 | Length: 308 / 328

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000117133	ribosome production factor 1 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	15	9	20
disruptive	5	15	11	32
missense	5	15	11	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	32	14	21
disruptive	8	42	23	58
missense	6	36	21	46

PlasmoDB Total SNPs: 80

Non-coding: 71 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 328 | Molecular Weight (kDa): 39.17

UniProt ID(s): C0H549

PDB ID(s): None

Isoelectric Point: 10.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007109	Brix domain
PFam	PF04427	Brix domain
Superfamily	SSF52954	N/A