About Gene List

PF3D7_0921900

Genome location: Pf3D7_09_v3:888,237..889,965(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.38 0.43
Trophozoite expressed 1.24 0.40
Schizont possibly expressed 0.29 0.83
Gametocyte expressed 0.67 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0921900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -2.916 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2T4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532328

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 14 5 24
disruptive 20 57 26 45
missense 20 53 25 38

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 28 12 15
disruptive 40 102 46 79
missense 33 82 33 56

PlasmoDB Total SNPs: 69

Non-coding: 38 | Synonymous: 8 | Nonsynonymous: 22 | Stop Codon: 1

Protein Information

Protein Length: 248 | Molecular Weight (kDa): 28.972

UniProt ID(s): Q8I2T4

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108