PF3D7_0922000

Genome location: Pf3D7_09_v3:890,057..893,267(+)

Genome classification: Core

Function and Localization

Product Description: dynein intermediate chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005858	axonemal dynein complex
Function	GO:0045504	dynein heavy chain binding
Function	GO:0045503	dynein light chain binding
Process	GO:0003341	cilium movement
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	not expressed	0.14	0.92
Schizont	not expressed	0.06	0.96
Gametocyte	possibly expressed	0.54	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0922000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.046 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2T3

"Best" AlphaFill ligand hit: MGT (7n-methyl-8-hydroguanosine-5'-triphosphate, Local RMSD=0.35) with 5H3T (Global RMSD=5.29)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104441

Most Similar Human Ortholog: A0A087WWV9

TM-align score: 0.69 | RMSD: 4.08

Seq Identity: 0.26 | Length: 539 / 820

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000122735	dynein axonemal intermediate chain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	47	21	62
disruptive	18	73	57	143
missense	18	69	56	133

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	81	38	65
disruptive	36	198	97	231
missense	29	168	88	166

PlasmoDB Total SNPs: 163

Non-coding: 123 | Synonymous: 22 | Nonsynonymous: 17 | Stop Codon: 1

Protein Information

Protein Length: 820 | Molecular Weight (kDa): 97.21

UniProt ID(s): Q8I2T3

PDB ID(s): None

Isoelectric Point: 7.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily