PF3D7_0922100

Genome location: Pf3D7_09_v3:894,280..901,286(+)

Genome classification: Core

Function and Localization

Product Description: ubiquitin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Function	GO:0031593	polyubiquitin modification-dependent protein binding
Process	GO:0006511	ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.68	0.34
Trophozoite	expressed	1.28	0.38
Schizont	expressed	0.50	0.71
Gametocyte	expressed	1.08	0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0922100

Resistome Missense Mutations: F1437V

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.784 | MFS: -2.366 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0823000)

Modification: Disrupted | RMgm-2399

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2T2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532338

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	74	59	87
disruptive	111	266	129	296
missense	55	192	104	230

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	156	81	96
disruptive	215	515	194	439
missense	103	375	154	286

PlasmoDB Total SNPs: 369

Non-coding: 137 | Synonymous: 120 | Nonsynonymous: 112 | Stop Codon: 0

Protein Information

Protein Length: 1542 | Molecular Weight (kDa): 182.087

UniProt ID(s): Q8I2T2

PDB ID(s): None

Isoelectric Point: 5.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000626	Ubiquitin-like domain
InterPro	IPR015496	Ubiquilin
InterPro	IPR029071	Ubiquitin-like domain superfamily
PFam	PF00240	Ubiquitin-like domain
Superfamily	SSF54236	Ubiquitin-like domain superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104