PF3D7_0922300

Genome location: Pf3D7_09_v3:905,998..908,357(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.85	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0922300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.684 | MFS: -2.068 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0823200)

Relative Growth Rate: 1.03 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0823200)

Modification: Disrupted | RMgm-2400

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H550

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215342

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	14	8	21
disruptive	1	12	12	38
missense	1	11	12	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	20	10	21
disruptive	4	40	36	76
missense	3	31	33	53

PlasmoDB Total SNPs: 169

Non-coding: 157 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 315 | Molecular Weight (kDa): 37.54

UniProt ID(s): C0H550

PDB ID(s): None

Isoelectric Point: 9.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A