PF3D7_0922800

Genome location: Pf3D7_09_v3:922,012..935,804(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0019901	protein kinase binding
Process	GO:0007165	signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.37	0.84
Trophozoite	expressed	1.44	0.36
Schizont	expressed	0.68	0.66
Gametocyte	possibly expressed	1.76	0.26

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0922800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.759 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533150

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	48	207	145	257
disruptive	190	621	394	909
missense	127	506	333	755

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	78	441	205	297
disruptive	361	1515	649	1443
missense	203	1171	521	908

PlasmoDB Total SNPs: 607

Non-coding: 91 | Synonymous: 318 | Nonsynonymous: 198 | Stop Codon: 0

Protein Information

Protein Length: 4255 | Molecular Weight (kDa): 516.458

UniProt ID(s): C0H552

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A