Product Description: perforin-like protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Component | GO:0020009 | microneme |
| Function | GO:0022829 | wide pore channel activity |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0923300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.574 | MFS: -2.428 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1006300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0824200)
Modification: Disrupted | RMgm-2407
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2S3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 40 | 35 | 47 |
| disruptive | 14 | 41 | 29 | 97 |
| missense | 14 | 41 | 28 | 94 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 84 | 36 | 54 |
| disruptive | 24 | 96 | 59 | 114 |
| missense | 20 | 88 | 59 | 97 |
PlasmoDB Total SNPs: 41
Non-coding: 0 | Synonymous: 22 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 821 | Molecular Weight (kDa): 93.291
UniProt ID(s): Q8I2S3
PDB ID(s): None
Isoelectric Point: 6.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| PFam | PF01823 | Membrane attack complex component/perforin (MACPF) domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15520375 | Essential role of membrane-attack protein in malarial transmission to mosquitohost. | Kadota K, Ishino T, ..., Yuda M | https://pubmed.ncbi.nlm.nih.gov/15520375/ |