About Gene List

PF3D7_0923400

Genome location: Pf3D7_09_v3:949,967..954,244(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.36 0.83
Trophozoite possibly expressed 0.89 0.53
Schizont not expressed 0.16 0.91
Gametocyte possibly expressed 0.60 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0923400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.998 | MFS: -1.901 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0824300)

Modification: Disrupted | RMgm-2408

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2S2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P05227 Histidine-rich protein PFHRP-II Plasmodium falciparum OrthoMCL BLAST CHEMBL152635CHEMBL2111198CHEMBL152052CHEMBL346177...

Orthology Information

Ortholog Group (OrthoMCL): OG6_533713

No human ortholog(s)

Protein Information

Protein Length: 1104 | Molecular Weight (kDa): 135.82

UniProt ID(s): Q8I2S2

PDB ID(s): None

Isoelectric Point: 6.52

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 33 27 71
disruptive 64 188 110 250
missense 34 139 93 205

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 90 43 65
disruptive 114 416 160 352
missense 57 322 126 233

PlasmoDB Total SNPs: 232

Non-coding: 75 | Synonymous: 90 | Nonsynonymous: 67 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104