PF3D7_0923700

Genome location: Pf3D7_09_v3:960,181..961,390(-)

Genome classification: Core

Function and Localization

Product Description: CFAP298 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0923700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.281 | MFS: -2.656 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0824600)

Relative Growth Rate: 1.04 ± 0.15
Confidence: 5.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0824600)

Modification: Disrupted | RMgm-2411

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H554

"Best" AlphaFill ligand hit: PIM (4-phenyl-1h-imidazole, Local RMSD=0.71) with 5BV5 (Global RMSD=18.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104560

Most Similar Human Ortholog: P57076

TM-align score: 0.81 | RMSD: 3.10

Seq Identity: 0.29 | Length: 267 / 280

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000159079	cilia and flagella associated protein 298

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	17	11	13
disruptive	1	25	21	58
missense	1	25	21	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	31	8	18
disruptive	3	85	40	100
missense	2	72	35	59

PlasmoDB Total SNPs: 56

Non-coding: 43 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 280 | Molecular Weight (kDa): 32.58

UniProt ID(s): C0H554

PDB ID(s): None

Isoelectric Point: 5.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR021298	Cilia- and flagella-associated protein 298
PFam	PF11069	Cilia- and flagella-associated protein 298
Superfamily	N/A	N/A