Product Description: polyadenylate-binding protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0008143 | poly(A) binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.13 | 0.50 |
| Trophozoite | expressed | 0.94 | 0.50 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.68 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0923900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.736 | MFS: -2.095 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2R8
"Best" AlphaFill ligand hit: STU (staurosporine, Local RMSD=9.20) with 4FR4 (Global RMSD=28.67)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q92843 | Bcl-2-like protein 2 | Homo sapiens | OrthoDB | MLS000080234MLS000080844MLS000082991MLS000097571... |
Ortholog Group (OrthoMCL): OG6_101686
Most Similar Human Ortholog: Q86U42
TM-align score: 0.60 | RMSD: 3.89
Seq Identity: 0.38 | Length: 150 / 202
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100836 | poly(A) binding protein nuclear 1 |
| ENSG00000258643 | BCL2L2-PABPN1 readthrough |
Protein Length: 202 | Molecular Weight (kDa): 22.979
UniProt ID(s): Q8I2R8
PDB ID(s): None
Isoelectric Point: 10.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 147
Non-coding: 131 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29359180 | Nuclear, Cytosolic, and Surface-Localized Poly(A)-Binding Proteins of Plasmodiumyoelii | Minns AM, Hart KJ, ..., Lindner SE | 10.1128/mSphere.00435-17 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34262344 | High-Expression of Cytoplasmic Poly (A) Binding Protein 1 (PABPC1) as a Prognostic Biomarker for Early-Stage Esophageal Squamous Cell Carcinoma | Pu J, Zhang T, ..., Long W | 10.2147/CMAR.S317631 |
| 31481099 | Impact of poly(A)-tail G-content on Arabidopsis PAB binding and their role in enhancing translational efficiency | Zhao T, Huan Q, ..., Cao X | 10.1186/s13059-019-1799-8 |
| 36275617 | Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei | Bezerra MJR, Moura DMN, ..., de Melo Neto OP | 10.3389/fmolb.2022.971811 |
| 37994298 | RRM1 and PAB domains of translation initiation factor eIF4G (Tif4631p) play acrucial role in the nuclear degradation of export-defective mRNAs inSaccharomyces cerevisiae | Saha U, Gaine R, ..., Das B | 10.1111/febs.17016 |
| 32532821 | The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-containingcomplexes in Trypanosoma brucei | Melo do Nascimento L, Terrao M, ..., Clayton C | 10.1074/jbc.RA120.013306 |
| 36823316 | Embryonic poly(A)-binding protein interacts with translation-related proteins andundergoes phosphorylation on the serine, threonine, and tyrosine residues in the mouse oocytes and early embryos | Ozturk S, Kosebent EG, ..., Can A | 10.1007/s10815-023-02746-7 |
| 36416579 | Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation | Rodriguez-Molina JB, Turtola M | 10.1002/2211-5463.13528 |
| 31898347 | mRNA Polyadenylation Machineries in Intestinal Protozoan Parasites | Ospina-Villa JD, Tovar-Ayona BJ, ..., Marchat LA | 10.1111/jeu.12781 |
| 31185899 | Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi andortholog to the yeast SR-protein Gbp2 | Wippel HH, Malgarin JS, ..., Alves LR | 10.1186/s12866-019-1505-8 |
| 34705820 | Identification of novel proteins and mRNAs differentially bound to the LeishmaniaPoly(A) Binding Proteins reveals a direct association between PABP1, theRNA-binding protein RBP23 and mRNAs encoding ribosomal proteins | Assis LA, Santos Filho MVC, ..., de Melo Neto OP | 10.1371/journal.pntd.0009899 |