PF3D7_0924200

Genome location: Pf3D7_09_v3:979,992..984,808(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	possibly expressed	0.30	0.81
Schizont	not expressed	0.10	0.93
Gametocyte	not expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0924200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.911 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2R5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532404

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	46	20	56
disruptive	50	100	69	149
missense	31	81	57	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	87	47	58
disruptive	72	224	123	230
missense	42	168	100	165

PlasmoDB Total SNPs: 260

Non-coding: 169 | Synonymous: 52 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1060 | Molecular Weight (kDa): 127.558

UniProt ID(s): Q8I2R5

PDB ID(s): None

Isoelectric Point: 8.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A