PF3D7_0924400

Genome location: Pf3D7_09_v3:987,949..993,032(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.85	0.65
Trophozoite	expressed	0.75	0.59
Schizont	expressed	1.06	0.49
Gametocyte	expressed	1.16	0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0924400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.908 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0825300)

Modification: Disrupted | RMgm-2414

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2R3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533618

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	61	31	65
disruptive	85	237	121	233
missense	47	186	101	173

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	123	41	63
disruptive	142	477	176	381
missense	80	360	144	235

PlasmoDB Total SNPs: 395

Non-coding: 136 | Synonymous: 155 | Nonsynonymous: 104 | Stop Codon: 0

Protein Information

Protein Length: 1245 | Molecular Weight (kDa): 144.68

UniProt ID(s): Q8I2R3

PDB ID(s): None

Isoelectric Point: 6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104