About Gene List

PF3D7_0924500

Genome location: Pf3D7_09_v3:993,199..998,110(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 14

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.13 0.93
Trophozoite expressed 0.42 0.75
Schizont expressed 0.71 0.61
Gametocyte expressed 0.65 0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0924500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -2.834 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0825400)

  • Relative Growth Rate: 0.04 ± 0.07
  • Confidence: 6.81

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H557

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533520

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 62 27 67
disruptive 87 161 77 177
missense 43 88 50 132

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 107 54 90
disruptive 144 313 123 309
missense 63 197 78 209

PlasmoDB Total SNPs: 397

Non-coding: 131 | Synonymous: 83 | Nonsynonymous: 183 | Stop Codon: 0

Protein Information

Protein Length: 1298 | Molecular Weight (kDa): 154.49

UniProt ID(s): C0H557

PDB ID(s): None

Isoelectric Point: 9.14

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095