PF3D7_0924600

Genome location: Pf3D7_09_v3:998,794..1,006,187(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.26	0.86
Schizont	expressed	0.86	0.57
Gametocyte	expressed	1.02	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0924600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.069 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2R1

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.52) with 3MMR (Global RMSD=16.01)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171031

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	78	58	134
disruptive	75	289	195	423
missense	43	255	179	378

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	173	89	169
disruptive	143	635	338	553
missense	78	540	287	419

PlasmoDB Total SNPs: 366

Non-coding: 115 | Synonymous: 139 | Nonsynonymous: 112 | Stop Codon: 0

Protein Information

Protein Length: 2082 | Molecular Weight (kDa): 247.155

UniProt ID(s): Q8I2R1

PDB ID(s): None

Isoelectric Point: 9.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A