Genome location: Pf3D7_09_v3:1,006,205..1,009,028(+)
Genome classification: Core
Product Description: splicing factor 3A subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.82 | 0.63 |
| Trophozoite | expressed | 0.83 | 0.55 |
| Schizont | expressed | 0.22 | 0.86 |
| Gametocyte | expressed | 0.69 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0924700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.116 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2R0
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.53) with 6MT9 (Global RMSD=15.73)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102364
Most Similar Human Ortholog: Q12874
TM-align score: 0.55 | RMSD: 4.17
Seq Identity: 0.28 | Length: 323 / 589
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000183431 | splicing factor 3a subunit 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 18 | 20 | 31 |
| disruptive | 8 | 43 | 19 | 80 |
| missense | 6 | 37 | 19 | 74 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 60 | 21 | 31 |
| disruptive | 17 | 114 | 71 | 150 |
| missense | 11 | 90 | 60 | 102 |
PlasmoDB Total SNPs: 131
Non-coding: 78 | Synonymous: 38 | Nonsynonymous: 15 | Stop Codon: 0
Protein Length: 589 | Molecular Weight (kDa): 71.385
UniProt ID(s): Q8I2R0
PDB ID(s): None
Isoelectric Point: 7.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021966 | Splicing factor SF3a60 binding domain |
| InterPro | IPR024598 | Splicing factor SF3a60 subunit C-terminal |
| InterPro | IPR031774 | SF3A3 domain |
| InterPro | IPR031776 | Splicing factor 3A subunit 3 |
| PFam | PF11931 | Splicing factor SF3a60 subunit C-terminal |
| PFam | PF12108 | Splicing factor SF3a60 binding domain |
| PFam | PF16837 | SF3A3 domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |