PF3D7_0924800 (TRF1)

Genome location: Pf3D7_09_v3:1,009,063..1,009,755(+)

Genome classification: Core

Function and Localization

Product Description: telomeric repeat binding factor 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	1.00
Schizont	no data	0.02	0.98
Gametocyte	no data	0.40	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0924800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: -3.721 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H558

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q15554	Telomeric repeat-binding factor 2		OrthoDB	CHEMBL4161856CHEMBL4165033CHEMBL4169779CHEMBL4172926...

Orthology Information

Ortholog Group (OrthoMCL): OG6_533190

No human ortholog(s)

Protein Information

Protein Length: 84 | Molecular Weight (kDa): 10.111

UniProt ID(s): C0H558

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009057	Homeobox-like domain superfamily
PFam	N/A	N/A
Superfamily	SSF46689	Homeobox-like domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	2	4
disruptive	2	5	10	10
missense	2	5	7	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	13	4	5
disruptive	4	15	17	11
missense	2	13	14	9

PlasmoDB Total SNPs: 72

Non-coding: 64 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0