PF3D7_0924900 (ATAT)

Genome location: Pf3D7_09_v3:1,010,380..1,011,822(+)

Genome classification: Core

Function and Localization

Product Description: alpha-tubulin N-acetyltransferase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.3.1.108 (Alpha-tubulin N-acetyltransferase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005874	microtubule

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.02	0.99
Gametocyte	possibly expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0924900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.268 | MFS: -0.729 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.3.1.108	alpha-tubulin N-acetyltransferase	CoAColchicine

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103430

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 184

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000137343	alpha tubulin acetyltransferase 1
ENSG00000206488	alpha tubulin acetyltransferase 1
ENSG00000223752	alpha tubulin acetyltransferase 1
ENSG00000229061	alpha tubulin acetyltransferase 1
ENSG00000231257	alpha tubulin acetyltransferase 1
ENSG00000234549	alpha tubulin acetyltransferase 1
ENSG00000235658	alpha tubulin acetyltransferase 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	6	3	12
disruptive	6	11	12	16
missense	6	11	11	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	12	11	17
disruptive	9	28	14	37
missense	9	23	12	26

PlasmoDB Total SNPs: 119

Non-coding: 104 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 184 | Molecular Weight (kDa): 21.835

UniProt ID(s): None

PDB ID(s): None

Isoelectric Point: 9.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007965	Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type
InterPro	IPR016181	Acyl-CoA N-acyltransferase
InterPro	IPR038746	Alpha-tubulin N-acetyltransferase
PFam	PF05301	Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type
Superfamily	SSF55729	Acyl-CoA N-acyltransferase