PF3D7_0925000

Genome location: Pf3D7_09_v3:1,011,837..1,014,313(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.08	0.95
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.68	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0925000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.228 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H560

"Best" AlphaFill ligand hit: ADE (adenine, Local RMSD=2.72) with 3WAZ (Global RMSD=14.09)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215343

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	7	8	22
disruptive	5	19	10	35
missense	5	17	9	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	25	17	16
disruptive	15	50	23	66
missense	11	37	18	42

PlasmoDB Total SNPs: 223

Non-coding: 206 | Synonymous: 10 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 220 | Molecular Weight (kDa): 26.529

UniProt ID(s): C0H560

PDB ID(s): None

Isoelectric Point: 8.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A