PF3D7_0925500 (TLP2)

Genome location: Pf3D7_09_v3:1,024,702..1,026,683(+)

Genome classification: Core

Function and Localization

Product Description: thioredoxin-like protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.05	0.97
Schizont	possibly expressed	0.05	0.97
Gametocyte	not expressed	0.05	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0925500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.15 | MFS: -3.426 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0826300)

Relative Growth Rate: 0.08 ± 0.05
Confidence: 7.27

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H561

"Best" AlphaFill ligand hit: 2CV (hega-10, Local RMSD=0.19) with 6H7N (Global RMSD=2.38)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
P10599	Thioredoxin	Homo sapiens	OrthoDB	GAMBOGIC ACIDCHEMBL2315288CHEMBL2315290CHEMBL2315292...
Q99757	Thioredoxin, mitochondrial	Homo sapiens	OrthoDB	GAMBOGIC ACID

Orthology Information

Ortholog Group (OrthoMCL): OG6_113982

No human ortholog(s)

Protein Information

Protein Length: 128 | Molecular Weight (kDa): 14.778

UniProt ID(s): C0H561

PDB ID(s): None

Isoelectric Point: 5.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013766	Thioredoxin domain
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF00085	Thioredoxin domain
Superfamily	SSF52833	Thioredoxin-like superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	4	4	7
disruptive	2	3	3	11
missense	2	3	3	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	14	3	10
disruptive	3	13	13	33
missense	2	10	11	26

PlasmoDB Total SNPs: 107

Non-coding: 101 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Associated Publications

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
21203490	Compartmentation of redox metabolism in malaria parasites.	Kehr S, Sturm N, ..., Becker K	10.1371/journal.ppat.1001242
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21
29655889	Composition characterization, antioxidant capacities and anti-proliferativeeffects of the polysaccharides isolated from Trametes lactinea (Berk.) Pat	He N, Tian L, ..., Zhao Y	10.1016/j.ijbiomac.2018.04.049
15297033	How does peripheral lipopolysaccharide induce gene expression in the brain ofrats?	Singh AK, Jiang Y	10.1016/j.tox.2004.04.015
37882562	PRMT5 regulates the polysaccharide content by controlling the splicing ofthaumatin-like protein in Ganoderma lucidum	Liu R, Yang Z, ..., Zhao M	10.1128/spectrum.02906-23